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In 2014 I joined the Laboratory of Cognitive and Computational Neuroscience, where I have been exploring genetic and lifestyle interactions using different neuroimaging techniques. I have particularly focused on the protective effect of physical activity in individuals at genetic risk for Alzheimer's disease, although I am also interested in diet patterns, sleep and bilingualism. I am also passionate about science communication and dissemination. I have been able to develop my PhD studies in a joint program between UAM (Spain) and ECU (Australia) thanks to a scholarship from La Caixa Foundation, and Endeavor Fellowship from the Australian Government, a PhD scholarship by the ECU School of Health and Medical Sciences and an Alumni Grant Spanish Scheme by the Australian Embassy in Spain.

Other research interests

Clinical neuroscience

This research line is focused on the clinical appliance of electrophysiological biomarkers. These biomarkers are developed by studying, with MEG and EEG, the electromagnetic brain activity of patients with neurological disorders. This line participates in the studies that involve patients with epilepsy, stroke, dementia, autism, or ADHD.

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Main publications


  • Ramírez-Toraño F, Bruña R, de Frutos-Lucas J, Rodríguez-Rojo IC, Marcos de Pedro S, Delgado-Losada ML, Gómez-Ruiz N, Barabash A, Marcos A, López Higes R, Maestú F. Functional Connectivity Hypersynchronization in Relatives of Alzheimer's Disease Patients: An Early E/I Balance Dysfunction? Cereb Cortex. 2021 Jan; 31(2):1201-1210. PubMed ID: 33108468. PDF file PDF file.


  • de Frutos-Lucas J, Cuesta P, Ramírez-Toraño F, Nebreda A, Cuadrado-Soto E, Peral-Suárez Á, Lopez-Sanz D, Bruña R, Marcos-de Pedro S, Delgado-Losada ML, López-Sobaler AM, Concepción Rodríguez-Rojo I, Barabash A, Serrano Rodriguez JM, Laws SM, Dolado AM, López-Higes R, Brown BM, Maestú F. Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Alzheimers Res Ther. 2020 09; 12(1):113. PubMed ID: 32962736.
  • de Frutos-Lucas J, Frost N, Erickson KI, Serrano JM, Maestu F, Laws SM, Brown BM. Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review. Ageing Res Rev. 2020 12; 64:101173. PubMed ID: 32961338.
  • de Frutos-Lucas J, Cuesta P, López-Sanz D, Peral-Suárez Á, Cuadrado-Soto E, Ramírez-Toraño F, Brown BM, Serrano JM, Laws SM, Rodríguez-Rojo IC, Verdejo-Román J, Bruña R, Delgado-Losada ML, Barabash A, López-Sobaler AM, López-Higes R, Marcos A, Maestú F. The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health. Alzheimers Res Ther. 2020 04; 12(1):48. PubMed ID: 32331531.


  • López-Sanz D, Bruña R, de Frutos-Lucas J, Maestú F. Magnetoencephalography applied to the study of Alzheimer's disease. Prog Mol Biol Transl Sci. 2019; 165:25-61. PubMed ID: 31481165.


  • Rodríguez-Rojo IC, Cuesta P, López ME, de Frutos-Lucas J, Bruña R, Pereda E, Barabash A, Montejo P, Montenegro-Peña M, Marcos A, López-Higes R, Fernández A, Maestú F. Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females. Front Neurosci. 2018; 12:684. PubMed ID: 30333719. PDF file PDF file.
  • López-Higes R, Prados JM, Rubio-Valdehita S, Rodríguez-Rojo I, de Frutos-Lucas J, Montenegro M, Montejo P, Prada D, Losada MLD. Factors Explaining Language Performance After Training in Elders With and Without Subjective Cognitive Decline. Front Aging Neurosci. 2018; 10:264. PubMed ID: 30233353.
  • de Frutos-Lucas J, López-Sanz D, Zuluaga P, Rodríguez-Rojo IC, Luna R, López ME, Delgado-Losada ML, Marcos A, Barabash A, López-Higes R, Maestú F, Fernández A. Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer's Disease: A MEG study. Clin Neurophysiol. 2018 09; 129(9):1981-1989. PubMed ID: 30031969. PDF file PDF file.
  • López-Higes R, Martín-Aragoneses MT, Rubio-Valdehita S, Delgado-Losada ML, Montejo P, Montenegro M, Prados JM, de Frutos-Lucas J, López-Sanz D. Efficacy of Cognitive Training in Older Adults with and without Subjective Cognitive Decline Is Associated with Inhibition Efficiency and Working Memory Span, Not with Cognitive Reserve. Front Aging Neurosci. 2018; 10:23. PubMed ID: 29456502.
  • Anderson JAE, Grundy JG, De Frutos J, Barker RM, Grady C, Bialystok E. Effects of bilingualism on white matter integrity in older adults. Neuroimage. 2018 02; 167:143-150. PubMed ID: 29175203.

Other publications

de Frutos-Lucas, J.; López-Sanz, D.; Cuesta, P.; Bruña, R.; … Maestú, F. (2019). “Enhancement of posterior brain functional networks in bilingual older adults”. Bilingualism: Language and Cognition. DOI: https://doi.org/10.1017/S1366728919000178

de Frutos-Lucas, J., Brown, B.M.; Porter, T.; Milicic, L.; …Laws, S. (2019). “Fighting inactivity to prevent cognitive decline: The role of dopamine in modulating physical activity levels in older adults”. 2nd HBP Student Conference – Transdisciplinary Research Linking Neuroscience, Brain Medicine and Computer Science. Frontiers Event Abstracts. DOI: 10.3389/978-2-88945-588-1

de Frutos-Lucas, J.; López-Sanz, D.; Susi, G. & Maestú, F. (2020). “Magnetoencephalography in Alzheimer´s Disese: Correlation with Current Biomarkers”. 50 years of MEG. Oxford University Press.

Susi, G.; de Frutos-Lucas, J; Niso, G.; Ye-Chen, S.M.; … Maestú, F. (2018). Healthy and Pathological Neurocognitive Aging: Spectral and Functional Connectivity Analyses Using Magnetoencephalography. Oxford Research Encyclopedia of Psychology and Aging. Oxford University Press.


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