I got the Degree of Medical Doctor (MD) in Santiago de Cuba Medical School in 1997, and specialized in Neurology at the National Institute of Neurology and Neurosurgery of Havana in 2002. I was awarded a Japanese Government (MONBUKAGAKUSHO) scholarship for training in clinical magnetoencephalography (MEG) research and for doctorate studies at Osaka University Graduate School of Medicine, Japan in 2005. I got a PhD degree in neuroscience in 2010. After that, I worked at the EuroEspes Biomedical Research Center in Corunna, where I acted as postdoctoral fellow and director of digital diagnosis (Electroencephalography - EEG, Optical Topography, Transcranial Doppler). Currently, I am a senior researcher at the Laboratory of Cognitive and Computational Neuroscience. My research interests include brain dysfunction in neuropsychiatric disorders such as epilepsy, stroke, Alzheimer’s disease, and schizophrenia, as well as clinical neuroimaging using MRI and neurophysiological techniques, in particular MEG and EEG.

Main publications


  • Ishii R, Canuet L. Global complexity and cognitive reserve in MCI. Clin Neurophysiol. 2014 Apr; 125(4):653-654. PubMed ID: 24210994.


  • Aoki Y, Kazui H, Tanaka T, Ishii R, Wada T, Ikeda S, Hata M, Canuet L, Musha T, Matsuzaki H, Imajo K, Yoshiyama K, Yoshida T, Shimizu Y, Nomura K, Iwase M, Takeda M. EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients. Neuroimage Clin. 2013; 3:522-30. PubMed ID: 24273735.
  • Ishii R, Canuet L, Aoki Y, Ikeda S, Hata M, Iwase M, Takeda M. Non-parametric permutation thresholding for adaptive nonlinear beamformer analysis on MEG revealed oscillatory neuronal dynamics in human brain. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:4807-10. PubMed ID: 24110810.
  • Aoki Y, Ishii R, Iwase M, Ikeda S, Hata M, Canuet L, Imajo K, Tanaka M, Matsuzaki H, Musha T, Takeda M. Normalized power variance change between pre-ictal and ictal phase of an epilepsy patient using NAT analysis: a case study. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:437-40. PubMed ID: 24109717.
  • Ishii R, Canuet L, Aoki Y, Ikeda S, Hata M, Takahashi H, Nakahachi T, Gunji A, Iwase M, Takeda M. Frequency diversity of posterior oscillatory activity in human revealed by spatial filtered MEG. J Integr Neurosci. 2013 Sep; 12(3):343-53. PubMed ID: 24070058.
  • Ishii R, Canuet L. EEG connectome: a new candidate for endophenotypes. Clin Neurophysiol. 2013 Dec; 124(12):2289-90. PubMed ID: 23968843.


  • Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R. Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study. PLoS One. 2012; 7(9):e46289. PubMed ID: 23050006.
  • Ishii R, Takahashi H, Kurimoto R, Aoki Y, Ikeda S, Hata M, Ikezawa K, Canuet L, Nakahachi T, Iwase M, Takeda M. [Endophenotypes in schizophrenia: a review of electrophysiological studies]. Seishin Shinkeigaku Zasshi. 2012; 114(6):629-46. PubMed ID: 22844814.
  • Ishii R, Canuet L. Heartbeat evoked potentials: a new possible clinical biomarker for depression based on the somatic marker hypothesis. Clin Neurophysiol. 2012 Oct; 123(10):1899-900. PubMed ID: 22502951.
  • Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M. Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects. Neurosci Res. 2012 Feb; 72(2):187-93. PubMed ID: 22062872.
  • Kurimoto R, Ishii R, Canuet L, Ikezawa K, Iwase M, Azechi M, Aoki Y, Ikeda S, Yoshida T, Takahashi H, Nakahachi T, Kazui H, Takeda M. Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment. Neuroimage. 2012 Feb; 59(4):4132-40. PubMed ID: 22047628.


  • Canuet L, Ishii R, Pascual-Marqui RD, Iwase M, Kurimoto R, Aoki Y, Ikeda S, Takahashi H, Nakahachi T, Takeda M. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy. PLoS One. 2011; 6(11):e27863. PubMed ID: 22125634.
  • Canuet L, Ikezawa K, Ishii R, Aoki Y, Iwase M, Takeda M. Schizophrenia-like psychosis associated with right-parietal meningioma. J Neuropsychiatry Clin Neurosci. 2011; 23(3):E36. PubMed ID: 21948922.
  • Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M. Decreased α event-related synchronization in the left posterior temporal cortex in schizophrenia: a magnetoencephalography-beamformer study. Neurosci Res. 2011 Nov; 71(3):235-43. PubMed ID: 21801762.
  • Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Aoki Y, Nakahachi T, Soriano S, Takeda M. Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy: Evidence from magnetoencephalography. Psychiatry Clin Neurosci. 2011 Mar; 65(2):183-90. PubMed ID: 21414092.
  • Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011 Mar; 43(3):326-32. PubMed ID: 20838929.


  • Ishii R, Canuet L, Kurimoto R, Ikezawa K, Aoki Y, Azechi M, Takahashi H, Nakahachi T, Iwase M, Kazui H, Takeda M. Frontal shift of posterior alpha activity is correlated with cognitive impairment in early Alzheimer's disease: a magnetoencephalography-beamformer study. Psychogeriatrics. 2010 Sep; 10(3):138-43. PubMed ID: 20860569.
  • Nakahachi T, Ishii R, Iwase M, Canuet L, Takahashi H, Kurimoto R, Ikezawa K, Azechi M, Kajimoto O, Takeda M. Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance. Behav Brain Res. 2010 Dec; 215(1):21-7. PubMed ID: 20600348.
  • Honaga E, Ishii R, Kurimoto R, Canuet L, Ikezawa K, Takahashi H, Nakahachi T, Iwase M, Mizuta I, Yoshimine T, Takeda M. Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder: an MEG study. Neurosci Lett. 2010 Jul; 478(3):141-5. PubMed ID: 20452402.
  • Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. Psychophysiology. 2010 Sep; 47(5):831-7. PubMed ID: 20233344.
  • Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Hashimoto R, Takeda M. Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography. Epilepsy Behav. 2010 Jan; 17(1):109-19. PubMed ID: 20004619.
  • Azechi M, Iwase M, Ikezawa K, Takahashi H, Canuet L, Kurimoto R, Nakahachi T, Ishii R, Fukumoto M, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M. Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: a near-infrared spectroscopy. Schizophr Res. 2010 Mar; 117(1):52-60. PubMed ID: 19896332.


  • Ishii R, Canuet L, Herdman A, Gunji A, Iwase M, Takahashi H, Nakahachi T, Hirata M, Robinson SE, Pantev C, Takeda M. Cortical oscillatory power changes during auditory oddball task revealed by spatially filtered magnetoencephalography. Clin Neurophysiol. 2009 Mar; 120(3):497-504. PubMed ID: 19138878.
  • Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Azechi M, Takahashi H, Nakahachi T, Teshima Y, Takeda M. Factors associated with impaired quality of life in younger and older adults with epilepsy. Epilepsy Res. 2009 Jan; 83(1):58-65. PubMed ID: 18976886.


  • Canuet L, Ishii R, Fernandez-Concepcion O, Iwase M, Takeda M. Severity of depressive symptoms as predictor of impairment of quality of life in chronic migraine: comparison with episodic migraine. Psychiatry Clin Neurosci. 2008 Dec; 62(6):738-40. PubMed ID: 19068012.
  • Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M. Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia. Neurosci Res. 2008 Nov; 62(3):187-94. PubMed ID: 18789980.
  • Canuet L, Ishii R, Iwase M, Kurimoto R, Ikezawa K, Azechi M, Wataya-Kaneda M, Takeda M. Tuberous sclerosis: localizing the epileptogenic tuber with synthetic aperture magnetometry with excess kurtosis analysis. J Clin Neurosci. 2008 Nov; 15(11):1296-8. PubMed ID: 18778940.
  • Ishii R, Canuet L, Ochi A, Xiang J, Imai K, Chan D, Iwase M, Takeda M, Snead OC, Otsubo H. Spatially filtered magnetoencephalography compared with electrocorticography to identify intrinsically epileptogenic focal cortical dysplasia. Epilepsy Res. 2008 Oct; 81(2-3):228-32. PubMed ID: 18672350.
  • Nakahachi T, Ishii R, Iwase M, Canuet L, Takahashi H, Kurimoto R, Ikezawa K, Azechi M, Sekiyama R, Honaga E, Uchiumi C, Iwakiri M, Motomura N, Takeda M. Frontal activity during the digit symbol substitution test determined by multichannel near-infrared spectroscopy. Neuropsychobiology. 2008; 57(4):151-8. PubMed ID: 18654084.
  • Kurimoto R, Ishii R, Canuet L, Ikezawa K, Azechi M, Iwase M, Yoshida T, Kazui H, Yoshimine T, Takeda M. Event-related synchronization of alpha activity in early Alzheimer's disease and mild cognitive impairment: an MEG study combining beamformer and group comparison. Neurosci Lett. 2008 Oct; 443(2):86-9. PubMed ID: 18634854.
  • Canuet L, Ishii R, Iwase M, Kurimoto R, Ikezawa K, Azechi M, Takahashi H, Nakahachi T, Takeda M. Cephalic auras of supplementary motor area origin: an ictal MEG and SAM(g2) study. Epilepsy Behav. 2008 Oct; 13(3):570-4. PubMed ID: 18585961.


  • Ishii R, Canuet L, Iwase M, Kurimoto R, Ikezawa K, Robinson SE, Ukai S, Shinosaki K, Hirata M, Yoshimine T, Takeda M. Right parietal activation during delusional state in episodic interictal psychosis of epilepsy: a report of two cases. Epilepsy Behav. 2006 Sep; 9(2):367-72. PubMed ID: 16884960.


  • Fernández-Concepción O, Canuet-Delis L. [Disability and quality of life in patients with migraine: determining factors]. Rev Neurol. 2003; 36(12):1105-12. PubMed ID: 12833226.

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