Clinical neuroscience

foto Research line coordinated by Pablo Cuesta.

Our research line focuses on cortical oscillations and brain functional connectivity in neuropsychiatric disorders, such as epilepsy, stroke, psychosis and autism. We use neurophysiological techniques, in particular Magntoencephalography (MEG) and Electroencephalography (EEG) in combination with neuropsychological, genetic and MRI volumetric data. We are particularly interested in understanding how altered patterns of functional connectivity 1) unveils pathophysiological mechanisms underlying seizures propagation and epilepsy-related cognitive impairment, and 2) can improve diagnosis of epilepsy and autism spectrum disorder.

Our research also looks at brain plasticity. We are interested in the effects of neurocognitive rehabilitation in the reorganization of brain networks after ischemic or hemorrhagic stroke, as well as in traumatic brain injury based on MEG changes in functional connectivity. This may potentially provide novel insight into how the brain works and recovers from illness.

Clinical neuroscience

Disrupted functional connectivity between cortical regions in a patient with left middle cerebral artery stroke

Selected publications


  • Aoki Y, Kazui H, Bruña R, Pascual-Marqui RD, Yoshiyama K, Wada T, Kanemoto H, Suzuki Y, Suehiro T, Matsumoto T, Kakeda K, Hata M, Canuet L, Ishii R, Iwase M, Ikeda M. Normalized power variance of eLORETA at high-convexity area predicts shunt response in idiopathic normal pressure hydrocephalus. Sci Rep. 2020 08; 10(1):13054. PubMed ID: 32747671.


  • Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R. Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study. PLoS One. 2012; 7(9):e46289. PubMed ID: 23050006.


  • Canuet L, Ishii R, Pascual-Marqui RD, Iwase M, Kurimoto R, Aoki Y, Ikeda S, Takahashi H, Nakahachi T, Takeda M. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy. PLoS One. 2011; 6(11):e27863. PubMed ID: 22125634.
  • Castellanos NP, Bajo R, Cuesta P, Villacorta-Atienza JA, Paúl N, Garcia-Prieto J, Del-Pozo F, Maestú F. Alteration and reorganization of functional networks: a new perspective in brain injury study. Front Hum Neurosci. 2011; 5:90. PubMed ID: 21960965. PDF file PDF file.
  • Castellanos NP, Leyva I, Buldú JM, Bajo R, Paúl N, Cuesta P, Ordóñez VE, Pascua CL, Boccaletti S, Maestú F, del-Pozo F. Principles of recovery from traumatic brain injury: reorganization of functional networks. Neuroimage. 2011 Apr; 55(3):1189-99. PubMed ID: 21195199. PDF file PDF file.


  • Castellanos NP, Paúl N, Ordóñez VE, Demuynck O, Bajo R, Campo P, Bilbao A, Ortiz T, del-Pozo F, Maestú F. Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury. Brain. 2010 Aug; 133(Pt 8):2365-81. PubMed ID: 20826433. PDF file PDF file.


  • Maestú F, Campo P, García-Morales I, del Barrio A, Paul N, del Pozo F, Ortiz T, Gil-Nagel A. Biomagnetic profiles of verbal memory success in patients with mesial temporal lobe epilepsy. Epilepsy Behav. 2009 Nov; 16(3):527-33. PubMed ID: 19818693.
  • García-Morales I, Maestú F, Pérez-Jiménez MA, Elices E, Ortiz T, Alvarez-Linera J, Gil-Nagel A. A clinical and magnetoencephalography study of MRI-negative startle epilepsy. Epilepsy Behav. 2009 Sep; 16(1):166-71. PubMed ID: 19635686.