Research team
Applied clinical neuroscience
In our Clinical Neuroscience Laboratory, we study brain activity using techniques such as magnetoencephalography (MEG) and high-density electroencephalography (EEG). We analyze cortical and functional connectivity oscillations in neurological and neuropsychiatric disorders such as epilepsy, stroke, head trauma, psychosis, and autism. These neurophysiological techniques provide direct measures of brain activity with exceptional temporal resolution. We also integrate neuropsychological, genetic, and magnetic resonance imaging (MRI) data to gain a more complete understanding of the brain mechanisms underlying these pathologies. We also investigate brain plasticity, focusing on how neuronal networks reorganize after ischemic or hemorrhagic stroke or traumatic brain injury, and how these processes can be modulated through neurocognitive rehabilitation. By analyzing changes in functional connectivity detected using MEG, we seek to better understand the brain’s mechanisms of adaptation and recovery following disease or injury. Our goal is to develop more accurate diagnostic tools and more effective therapeutic strategies that contribute to improving the quality of life of people affected by neurological and psychiatric disorders. In this way, we seek to provide a deeper understanding of brain function and its resilience.
Likewise, the Clinical Neuroscience Laboratory constitutes the clinical arm of the C3N, responsible for the direct application of this knowledge and technology in the clinical setting. This clinical activity includes pre-surgical evaluation in epilepsy, monitoring of neurological recovery after stroke or head trauma, and the characterization of neurocognitive profiles in neurodevelopmental and psychiatric disorders. The data obtained are integrated with the findings of the C3N’s basic research, in a translational effort to improve diagnostic accuracy, prognoses, and the development of personalized therapeutic interventions.
In addition to our clinical and research activities, the Clinical Neuroscience Laboratory plays a fundamental role in the training of future professionals in the field of neurophysiology. The laboratory is responsible for the theoretical and practical training of the technicians and specialists who will operate the Center’s EEG and MEG equipment. Through structured training programs and direct supervision by experts, the acquisition of the necessary skills for the correct acquisition, processing, and interpretation of neurophysiological data is guaranteed,
Selected publications
2020
Aoki Y, Kazui H, Bruña R, Pascual-Marqui RD, Yoshiyama K, Wada T, Kanemoto H, Suzuki Y, Suehiro T, Matsumoto T, Kakeda K, Hata M, Canuet L, Ishii R, Iwase M, Ikeda M. Normalized power variance of eLORETA at high-convexity area predicts shunt response in idiopathic normal pressure hydrocephalus. Sci Rep. 2020 08; 10(1):13054. PubMed ID: 32747671.
2012
Canuet L, Tellado I, Couceiro V, Fraile C, Fernandez-Novoa L, Ishii R, Takeda M, Cacabelos R. Resting-state network disruption and APOE genotype in Alzheimer’s disease: a lagged functional connectivity study. PLoS One. 2012; 7(9):e46289. PubMed ID: 23050006.
2011
Canuet L, Ishii R, Pascual-Marqui RD, Iwase M, Kurimoto R, Aoki Y, Ikeda S, Takahashi H, Nakahachi T, Takeda M. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy. PLoS One. 2011; 6(11):e27863. PubMed ID: 22125634.
Castellanos NP, Bajo R, Cuesta P, Villacorta-Atienza JA, Paúl N, Garcia-Prieto J, Del-Pozo F, Maestú F. Alteration and reorganization of functional networks: a new perspective in brain injury study. Front Hum Neurosci. 2011; 5:90. PubMed ID: 21960965. PDF file.
Castellanos NP, Leyva I, Buldú JM, Bajo R, Paúl N, Cuesta P, Ordóñez VE, Pascua CL, Boccaletti S, Maestú F, del-Pozo F. Principles of recovery from traumatic brain injury: reorganization of functional networks. Neuroimage. 2011 Apr; 55(3):1189-99. PubMed ID: 21195199. PDF file.
2010
Castellanos NP, Paúl N, Ordóñez VE, Demuynck O, Bajo R, Campo P, Bilbao A, Ortiz T, del-Pozo F, Maestú F. Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury. Brain. 2010 Aug; 133(Pt 8):2365-81. PubMed ID: 20826433. PDF file.
2009
Maestú F, Campo P, García-Morales I, del Barrio A, Paul N, del Pozo F, Ortiz T, Gil-Nagel A. Biomagnetic profiles of verbal memory success in patients with mesial temporal lobe epilepsy. Epilepsy Behav. 2009 Nov; 16(3):527-33. PubMed ID: 19818693.
