Research team
Pathological aging
This line of research seeks to understand the relationship between normal aging processes and neuropsychiatric pathologies that occur in aging. This line of research began in 2000 and has been one of the most successful in the history of C3N, in terms of the number of publications and successful research projects. MEG and EEG are excellent biomarkers of early synaptic dysfunction that occur in these pathologies, and their data are associated with cognitive/emotional performance and with biomolecular and magnetic resonance biomarker data. International collaboration will be encouraged, and we will continue researching computational neuroscience models, as well as neuromodulation mechanisms and cognitive interventions to determine how they modify the functional network alterations observed in neurophysiological recordings.
Selected publications
- Javed E, Suárez-Méndez I, Susi G, Román JV, Palva JM, Maestú F, Palva S. A Shift Toward Supercritical Brain Dynamics Predicts Alzheimer’s Disease Progression. J Neurosci. 2025 Feb 26;45(9):e0688242024. doi: 10.1523/JNEUROSCI.0688-24.2024
- García-Colomo A, López-Sanz D, Taguas I, Carrasco-Gómez M, Spuch C, Comis-Tuche M, Maestú F. Effects of Alzheimer’s disease plasma marker levels on multilayer centrality in healthy individuals. Alzheimers Res Ther. 2025 Jan 6;17(1):8. doi: 10.1186/s13195-024-01654-x
- García-Colomo A, López-Sanz D, Stam CJ, Hillebrand A, Carrasco-Gómez M, Spuch C, Comis-Tuche M, Maestú F. Minimum spanning tree analysis of unimpaired individuals at risk of Alzheimer’s disease. Brain Commun. 2024 Aug 20;6(5):fcae283. doi: 10.1093/braincomms/fcae283. eCollection 2024
- García-Colomo A, Nebreda A, Carrasco-Gómez M, de Frutos-Lucas J, Ramirez-Toraño F, Spuch C, Comis-Tuche M, Bruña R, Alfonsín S, Maestú F. Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease. Geroscience. 2024 Jun;46(3):2989-3003. doi: 10.1007/s11357-023-01036-5.
- Chino B, Cuesta P, Pacios J, de Frutos-Lucas J, Torres-Simón L, Doval S, Marcos A, Bruña R, Maestú F. Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals. Geroscience. 2023 Feb;45(1):477-489. doi: 10.1007/s11357-022-00656-7.
