UCM’s C3N leads the PREDICE-CM consortium for early diagnosis and intervention in Alzheimer’s disease

The Cognitive and Computational Neuroscience Laboratory (C3N) heads an ambitious biomedical consortium funded by the Community of Madrid. The PREDICE-CM program seeks to establish an innovative protocol for the early detection and treatment of Alzheimer’s disease, joining forces with leading institutions in clinical and technological research.

Within the framework of the recent presentation of the 2026 health programs and VII PRICIT-CAM, PREDICE-CM has been officially unveiled. The project, coordinated by the Complutense University of Madrid (UCM), features the active participation of top-tier researchers from leading entities such as the Health Research Institute of the Hospital Clínico San Carlos (IdISSC), the Foundation for Biomedical Research of the Hospital Universitario de La Princesa (FIBHULP), and the Polytechnic University of Madrid (UPM).

On a technical level, the project stands out for its use of state-of-the-art infrastructure, such as magnetoencephalography (MEG) and temporal interference neuromodulation. The consortium will integrate biosignals, cognitive data, and blood biomarkers through artificial intelligence algorithms, building a computational neuroscience model capable of estimating the risk of dementia and modulating pathological brain activity safely and non-invasively.

Fernando Maestú and Mª Eugenia López, the principal investigators coordinating the project from the UCM, highlight the clinical dimension of this initiative: “Our main challenge is to develop a protocol for early diagnosis and intervention in Alzheimer’s disease. Through multimodal data integration and focal neuromodulation tools targeting deep brain regions, we are connecting science, people, and society to achieve real clinical impact.”

We are grateful for the fundamental support of the Community of Madrid through its R&D programs. This investment in translational science reaffirms the commitment of the Complutense University and its associated centers to successful aging, enabling the research developed at the C3N to be transformed into tangible tools for the well-being of society.

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