I completed my Bachelor's in Telecommunication Engineering from Universidad Politécnica de Madrid in 2015 and I completed my Master's in Biomedical Engineering also from Universidad Politécnica de Madrid in 2016. After a few collaborations with hospitals as an external biostatistical analyst, but overall, after I  met Fernando Maestu, I decided to pursue a PhD in Biomedical Engineering. My research project is focused on the characterization of Alzheimer's disease, especially, the early detection of the disease. My area of expertise is signal processing and magnetoencephalography technique. In 2020, I'm honoured to do my research stay working with Prof. Joaquín Goñi and his team in the CONNplexity Lab. We will apply theirs novelty methods to joint functional connectivity (obtained from magnetoencephalography signals) and structural connectivity (obtained from DWI). My aim is to study how structural connectivity modulates functional connectivity and how this mutual information can be used to characterize better the early stages of Alzheimer's disease.

Other research interests

Data analysis

Research on and application of data analysis methods in our laboratory focuses on functional connectivity, preprocessing methods, classification, source reconstruction and Bayesian models. We have developed the publicly available connectivity toolbox HERMES.

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Main publications


  • López-Cuenca I, de Hoz R, Alcántara-Rey C, Salobrar-García E, Elvira-Hurtado L, Fernández-Albarral JA, Barabash A, Ramírez-Toraño F, de Frutos-Lucas J, Salazar JJ, Ramírez AI, Ramírez JM. Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer's Disease. Biomedicines. 2021 Jun; 9(6):. PubMed ID: 34199664.
  • Ramírez-Toraño F, García-Alba J, Bruña R, Esteba-Castillo S, Vaquero L, Pereda E, Maestú F, Fernández A. Hypersynchronized Magnetoencephalography Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer's Disease in Down Syndrome. Brain Connect. 2021 Jun; In press. PubMed ID: 33858203.
  • Ramírez-Toraño F, Bruña R, de Frutos-Lucas J, Rodríguez-Rojo IC, Marcos de Pedro S, Delgado-Losada ML, Gómez-Ruiz N, Barabash A, Marcos A, López Higes R, Maestú F. Functional Connectivity Hypersynchronization in Relatives of Alzheimer's Disease Patients: An Early E/I Balance Dysfunction? Cereb Cortex. 2021 Jan; 31(2):1201-1210. PubMed ID: 33108468. PDF file PDF file.


  • de Frutos-Lucas J, Cuesta P, Ramírez-Toraño F, Nebreda A, Cuadrado-Soto E, Peral-Suárez Á, Lopez-Sanz D, Bruña R, Marcos-de Pedro S, Delgado-Losada ML, López-Sobaler AM, Concepción Rodríguez-Rojo I, Barabash A, Serrano Rodriguez JM, Laws SM, Dolado AM, López-Higes R, Brown BM, Maestú F. Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Alzheimers Res Ther. 2020 09; 12(1):113. PubMed ID: 32962736.
  • de Frutos-Lucas J, Cuesta P, López-Sanz D, Peral-Suárez Á, Cuadrado-Soto E, Ramírez-Toraño F, Brown BM, Serrano JM, Laws SM, Rodríguez-Rojo IC, Verdejo-Román J, Bruña R, Delgado-Losada ML, Barabash A, López-Sobaler AM, López-Higes R, Marcos A, Maestú F. The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health. Alzheimers Res Ther. 2020 04; 12(1):48. PubMed ID: 32331531.


  • García-Alba J, Ramírez-Toraño F, Esteba-Castillo S, Bruña R, Moldenhauer F, Novell R, Romero-Medina V, Maestú F, Fernández A. Neuropsychological and neurophysiological characterization of mild cognitive impairment and Alzheimer's disease in Down syndrome. Neurobiol Aging. 2019 12; 84:70-79. PubMed ID: 31518951.

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