Navigation

You are here: Home › Members of the Center › Senior researchers › Pablo Cuesta
foto

Pablo Cuesta

Senior researcher
Clinical neuroscience

Email: pablo.cuesta@ucm.es
Phone number: (+34) 91 3364656 ext. 24624
ORCID: 0000-0002-8459-3354
Google scholar: https://scholar.google.es/citations?user=gnwbFSkAAAAJ&hl=es&authuser=1
ResearchGate: https://www.researchgate.net/profile/Pablo_Cuesta2/

Degree in Physics. MSC Biomedical Physics. PhD Physics (neuroscience). Current recipient at Universidad Complutense de Madrid, of a Juan de la Cierva Incorporación grant from the spanish government.
Since 2010, I have been one of the researchers working out the projects on Alzheimer's Disease (AD) and epilepsy. I have also collaborated in the development of analysis methodologies for multimodal data integration (e.g. MRI, MEG, EEG, PET, neuropsychological assessments and neurobiological and genetic markers). Currently, my work is focused in three main lines: 1) assessing electrophysiological profiles associated with the prodromal stages of AD; 2) In association with the Children's Memorial Hermann Hospital in Houston, we are developing computational models of surgery in enfants patients with drug-resistant epilepsy; 3) in association with San Diego State University, we study how brain alterations caused by alcohol intake are modulated by certain genetic factors related to the availability of dopamine in the cerebral cortex.
I am (or have been) reviewer for different scientific journals (e.g. Frontiers, Neurobiology of Aging, Scientific Reports, Neuroimage and Journal of Alzheimer’s Disease). I have been living abroad for almost 3 years, visiting: Goldsmiths (University of London), Memory and Aging Center (University of California San Francisco), NCGG of Japan, San Diego State University and the Children's Memorial Hermann Hospital in Houston.

Other research interests

Computational neuroscience

Computational neuroscience is an interdisciplinary field which employs mathematical models and theoretical analysis to understand the principles that govern the physiology, structure and development of the nervous system, and related cognitive abilities. Specifically, in the laboratory we carry out brain network simulations based on real data, aimed at reproducing network connectivity in health and disease. A parallel activity concerning this research area is the application of brain-like processing strategies to address engineering problems.

Read more

Data analysis

Research on and application of data analysis methods in our laboratory focuses on functional connectivity, preprocessing methods, classification, source reconstruction and Bayesian models. We have developed the publicly available connectivity toolbox HERMES.

Read more

Healthy and pathological aging

Read more

Main publications

2021

  • Correas A, Cuesta P, Rosen BQ, Maestu F, Marinkovic K. Compensatory neuroadaptation to binge drinking: Human evidence for allostasis. Addict Biol. 2021 05; 26(3):e12960. PubMed ID: 32885571.

2020

  • de Frutos-Lucas J, Cuesta P, Ramírez-Toraño F, Nebreda A, Cuadrado-Soto E, Peral-Suárez Á, Lopez-Sanz D, Bruña R, Marcos-de Pedro S, Delgado-Losada ML, López-Sobaler AM, Concepción Rodríguez-Rojo I, Barabash A, Serrano Rodriguez JM, Laws SM, Dolado AM, López-Higes R, Brown BM, Maestú F. Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Alzheimers Res Ther. 2020 09; 12(1):113. PubMed ID: 32962736.
  • López ME, Turrero A, Cuesta P, Rodríguez-Rojo IC, Barabash A, Marcos A, Maestú F, Fernández A. A multivariate model of time to conversion from mild cognitive impairment to Alzheimer's disease. Geroscience. 2020 12; 42(6):1715-1732. PubMed ID: 32886293.
  • de Frutos-Lucas J, Cuesta P, López-Sanz D, Peral-Suárez Á, Cuadrado-Soto E, Ramírez-Toraño F, Brown BM, Serrano JM, Laws SM, Rodríguez-Rojo IC, Verdejo-Román J, Bruña R, Delgado-Losada ML, Barabash A, López-Sobaler AM, López-Higes R, Marcos A, Maestú F. The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health. Alzheimers Res Ther. 2020 04; 12(1):48. PubMed ID: 32331531.

2019

  • Pusil S, López ME, Cuesta P, Bruña R, Pereda E, Maestú F. Hypersynchronization in mild cognitive impairment: the 'X' model. Brain. 2019 12; 142(12):3936-3950. PubMed ID: 31633176. PDF file PDF file.
  • Maestú F, Cuesta P, Hasan O, Fernandéz A, Funke M, Schulz PE. Corrigendum: The Importance of the Validation of M/EEG With Current Biomarkers in Alzheimer's Disease. Front Hum Neurosci. 2019; 13:81. PubMed ID: 30894809.
  • Maestú F, Cuesta P, Hasan O, Fernandéz A, Funke M, Schulz PE. The Importance of the Validation of M/EEG With Current Biomarkers in Alzheimer's Disease. Front Hum Neurosci. 2019; 13:17. PubMed ID: 30792632.

2018

  • Rodríguez-Rojo IC, Cuesta P, López ME, de Frutos-Lucas J, Bruña R, Pereda E, Barabash A, Montejo P, Montenegro-Peña M, Marcos A, López-Higes R, Fernández A, Maestú F. Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females. Front Neurosci. 2018; 12:684. PubMed ID: 30333719. PDF file PDF file.
  • Dimitriadis SI, López ME, Bruña R, Cuesta P, Marcos A, Maestú F, Pereda E. How to Build a Functional Connectomic Biomarker for Mild Cognitive Impairment From Source Reconstructed MEG Resting-State Activity: The Combination of ROI Representation and Connectivity Estimator Matters. Front Neurosci. 2018; 12:306. PubMed ID: 29910704. PDF file PDF file.
  • Nakamura A, Cuesta P, Fernández A, Arahata Y, Iwata K, Kuratsubo I, Bundo M, Hattori H, Sakurai T, Fukuda K, Washimi Y, Endo H, Takeda A, Diers K, Bajo R, Maestú F, Ito K, Kato T. Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease. Brain. 2018 05; 141(5):1470-1485. PubMed ID: 29522156. PDF file PDF file.

2017

  • Nakamura A, Cuesta P, Kato T, Arahata Y, Iwata K, Yamagishi M, Kuratsubo I, Kato K, Bundo M, Diers K, Fernández A, Maestú F, Ito K. Early functional network alterations in asymptomatic elders at risk for Alzheimer's disease. Sci Rep. 2017 07; 7(1):6517. PubMed ID: 28747760.

2016

  • Correas A, Cuesta P, López-Caneda E, Rodríguez Holguín S, García-Moreno LM, Pineda-Pardo JA, Cadaveira F, Maestú F. Functional and structural brain connectivity of young binge drinkers: a follow-up study. Sci Rep. 2016 08; 6:31293. PubMed ID: 27506835.
  • López ME, Turrero A, Cuesta P, López-Sanz D, Bruña R, Marcos A, Gil P, Yus M, Barabash A, Cabranes JA, Maestú F, Fernández A. Searching for Primary Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Multivariate Follow-Up Study. J Alzheimers Dis. 2016 03; 52(1):133-43. PubMed ID: 27060953. PDF file PDF file.
  • Kort NS, Cuesta P, Houde JF, Nagarajan SS. Bihemispheric network dynamics coordinating vocal feedback control. Hum Brain Mapp. 2016 Apr; 37(4):1474-85. PubMed ID: 26917046.

2015

  • Maestú F, Peña JM, Garcés P, González S, Bajo R, Bagic A, Cuesta P, Funke M, Mäkelä JP, Menasalvas E, Nakamura A, Parkkonen L, López ME, Del Pozo F, Sudre G, Zamrini E, Pekkonen E, Henson RN, Becker JT, . A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity. Neuroimage Clin. 2015; 9:103-9. PubMed ID: 26448910. PDF file PDF file.
  • Canuet L, Pusil S, López ME, Bajo R, Pineda-Pardo JÁ, Cuesta P, Gálvez G, Gaztelu JM, Lourido D, García-Ribas G, Maestú F. Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment. J Neurosci. 2015 Jul; 35(28):10325-30. PubMed ID: 26180207. PDF file PDF file.
  • Correas A, Rodriguez Holguín S, Cuesta P, López-Caneda E, García-Moreno LM, Cadaveira F, Maestú F. Exploratory Analysis of Power Spectrum and Functional Connectivity During Resting State in Young Binge Drinkers: A MEG Study. Int J Neural Syst. 2015 May; 25(3):1550008. PubMed ID: 25753601.
  • Cuesta P, Garcés P, Castellanos NP, López ME, Aurtenetxe S, Bajo R, Pineda-Pardo JA, Bruña R, Marín AG, Delgado M, Barabash A, Ancín I, Cabranes JA, Fernandez A, Del Pozo F, Sancho M, Marcos A, Nakamura A, Maestú F. Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space. J Alzheimers Dis. 2015; 44(2):493-505. PubMed ID: 25281603. PDF file PDF file.
  • Cuesta P, Barabash A, Aurtenetxe S, Garcés P, López ME, Bajo R, Llanero-Luque M, Ancín I, Cabranes JA, Marcos A, Sancho M, Nakamura A, Maestú F, Fernandez A. Source analysis of spontaneous magnetoencephalograpic activity in healthy aging and mild cognitive impairment: influence of apolipoprotein E polymorphism. J Alzheimers Dis. 2015; 43(1):259-73. PubMed ID: 25079806. PDF file PDF file.

2014

  • López ME, Aurtenetxe S, Pereda E, Cuesta P, Castellanos NP, Bruña R, Niso G, Maestú F, Bajo R. Cognitive reserve is associated with the functional organization of the brain in healthy aging: a MEG study. Front Aging Neurosci. 2014; 6:125. PubMed ID: 24982632. PDF file PDF file.
  • López ME, Garcés P, Cuesta P, Castellanos NP, Aurtenetxe S, Bajo R, Marcos A, Montenegro M, Yubero R, del Pozo F, Sancho M, Maestú F. Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study. Age (Dordr). 2014 Jun; 36(3):9643. PubMed ID: 24658709. PDF file PDF file.
  • Pineda-Pardo JA, Garcés P, López ME, Aurtenetxe S, Cuesta P, Marcos A, Montejo P, Yus M, Hernández-Tamames JA, del Pozo F, Becker JT, Maestú F. White matter damage disorganizes brain functional networks in amnestic mild cognitive impairment. Brain Connect. 2014 Jun; 4(5):312-22. PubMed ID: 24617580. PDF file PDF file.
  • López ME, Cuesta P, Garcés P, Castellanos PN, Aurtenetxe S, Bajo R, Marcos A, Delgado ML, Montejo P, López-Pantoja JL, Maestú F, Fernandez A. MEG spectral analysis in subtypes of mild cognitive impairment. Age (Dordr). 2014 Jun; 36(3):9624. PubMed ID: 24532390. PDF file PDF file.

2012

  • del Río D, Cuesta P, Bajo R, García-Pacios J, López-Higes R, del-Pozo F, Maestú F. Efficiency at rest: magnetoencephalographic resting-state connectivity and individual differences in verbal working memory. Int J Psychophysiol. 2012 Nov; 86(2):160-7. PubMed ID: 22940641. PDF file PDF file.
  • Becker JT, Cuesta P, Fabrizio M, Sudre G, Vergis EN, Douaihy A, Bajo R, Schubert A, Lopez OL, Parkkonen L, Maestu F, Bagic A. Brain structural and functional recovery following initiation of combination antiretroviral therapy. J Neurovirol. 2012 Oct; 18(5):423-7. PubMed ID: 22692914.
  • Bajo R, Castellanos NP, Cuesta P, Aurtenetxe S, Garcia-Prieto J, Gil-Gregorio P, del-Pozo F, Maestu F. Differential patterns of connectivity in progressive mild cognitive impairment. Brain Connect. 2012; 2(1):21-4. PubMed ID: 22458376. PDF file PDF file.
  • Becker JT, Bajo R, Fabrizio M, Sudre G, Cuesta P, Aizenstein HJ, Lopez OL, Wolk D, Parkkonen L, Maestu F, Bagic A. Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. Brain Imaging Behav. 2012 Sep; 6(3):366-73. PubMed ID: 22328062. PDF file PDF file.

2011

  • Castellanos NP, Bajo R, Cuesta P, Villacorta-Atienza JA, Paúl N, Garcia-Prieto J, Del-Pozo F, Maestú F. Alteration and reorganization of functional networks: a new perspective in brain injury study. Front Hum Neurosci. 2011; 5:90. PubMed ID: 21960965. PDF file PDF file.
  • Castellanos NP, Leyva I, Buldú JM, Bajo R, Paúl N, Cuesta P, Ordóñez VE, Pascua CL, Boccaletti S, Maestú F, del-Pozo F. Principles of recovery from traumatic brain injury: reorganization of functional networks. Neuroimage. 2011 Apr; 55(3):1189-99. PubMed ID: 21195199. PDF file PDF file.

Other publications

Jaisalmer de Frutos-Lucas, David López-Sanz, Pablo Cuesta, Ricardo Bruña, Sofía de la Fuente, Noelia Serrano, María Eugenia López, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos, and Fernando Maestú. Enhancement of posterior brain functional networks in bilingual older adults. Bilingualism: Language and Cognition. 2019; https://doi.org/10.1017/S1366728919000178

Nazareth P. Castellanos, Elisa Rodríguez-Toscano, Javier García-Pacios, Pilar Garcés, Nuria Paúl, Pablo Cuesta, Ricardo Bajo, Francisco del-Pozo, Fernando Maestú. Restoring of brain entropy and complexity after rehabilitation of traumatic brain injury. Functional Neurology, Rehabilitation, and Ergonomics. 2013; Volume 2 Issue 3.

Electronic versions are provided as a professional courtesy to ensure timely dissemination of academic work for individual, noncommercial purposes. Copyright (and all rights therein) resides with the respective copyright holders, as stated within each paper. These files may not be reposted without permission.